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Article

SCN5A channelopathies--an update on mutations and mechanisms.

Progress in biophysics and molecular biology - 1 Jan 2000

Zimmer Thomas, Surber Ralf

Abstract excerpt

Voltage-gated Na+ channels mediate the rapid upstroke of the action potential in excitable tissues. Na(v)1.5, encoded by the SCN5A gene, is the predominant isoform in the heart. Mutations in SCN5A are associated with distinct cardiac excitation disorders often resulting in life-threatening arrhythmias. This review outlines the currently known SCN5A mutations linked to three distinct cardiac rhythm disorders: long...

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Identifiers

PMID: 19027780
DOI: 10.1016/j.pbiomolbio.2008.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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