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Article

SCN5A Cardiomyopathy: from Ion Channel Dysfunction To Clinical Disease.

Current cardiology reports - 9 Oct 2025

Heymans Astrid B M, Bianchi Lorenzo, Volders Paul G A, van der Crabben Saskia N, Verdonschot Job A J

Abstract excerpt

PURPOSE OF REVIEW: Although SCN5A variants are an established cause of arrhythmia and conduction disease, their association with dilated cardiomyopathy (DCM) is less studied. This review summarizes recent insights into SCN5A-related cardiomyopathy, focusing on genotype-phenotype correlations, overlap with arrhythmia, and implications for management. RECENT FINDINGS: Both gain- and loss-of-function SCN5A variants...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41065902
DOI: 10.1007/s11886-025-02298-5
PMCID: PMC12511166

Genes

SCN5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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