Risk Factors for the Progression from Low to High Titres in 260 Children with Severe Haemophilia A and Newly Developed Inhibitors.

doi:10.1160/TH17-01-0059

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Risk Factors for the Progression from Low to High Titres in 260 Children with Severe Haemophilia A and Newly Developed Inhibitors.

Thrombosis and haemostasis - 1 Dec 2017

Mancuso Maria Elisa, Fischer Kathelijn, Santagostino Elena, Oldenburg Johannes, Platokouki Helen, Königs Cristoph, Escuriola-Ettingshausen Carmen, Rivard George E, Cid Ana Rosa, Carcao Manuel, Ljung Rolf, Petrini Pia, Altisent Carmen, Kenet Gili, Liesner Raina, Kurnik Karin, Auerswald Günther, Chambost Hérvè, Mäkipernaa Anne, Molinari Angelo Claudio, Williams Mike, van den Berg H Marijke

Abstract excerpt

In children with severe haemophilia A, inhibitors to factor VIII (FVIII) usually develop during the first 50 treatment exposure days and are classified as low or high titre depending on the peak inhibitor titre being greater or less than 5 Bethesda units/mL (BU/mL). Classification of the inhibitor may change with time, as some low-titre inhibitors progress to high titre following re-exposure to FVIII concentrate....

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PMID: 29212115
DOI: 10.1160/TH17-01-0059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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