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Article

Immune tolerance induction for the eradication of inhibitors in patients with hemophilia A.

Expert opinion on biological therapy - 1 Dec 2008

Kruse-Jarres Rebecca, Barnett Brian, Leissinger Cindy

Abstract excerpt

BACKGROUND: Both genetic and environmental factors contribute to the formation of alloantibodies that bind to functional domains on the Factor VIII (FVIII) molecule and inhibit its function. Patients with hemophilia A who develop high-titer inhibitors are at increased risk for serious hemorrhage and disability, particularly arthropathy, because bleeding events do not respond to standard therapy. Immune tolerance...

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Autoantibodies
Factor VIII
Genetic Predisposition to Disease
Hemophilia A
Immune Tolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18990076
DOI: 10.1517/14712590802515537

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