Article
Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.
Nature aging - 1 Feb 2023
Zhang Na, Hu Qianying, Sui Tingting, Fu Lu, Zhang Xinglin, Wang Yu, Zhu Xiaojuan, Huang Baiqu, Lu Jun, Li Zhanjun, Zhang Yu
Abstract excerpt
An accumulating body of evidence indicates an association between mitotic defects and the aging process in Hutchinson-Gilford progeria syndrome (HGPS), which is a premature aging disease caused by progerin accumulation. Here, we found that BUBR1, a core component of the spindle assembly checkpoint, was downregulated during HGPS cellular senescence. The remaining BUBR1 was anchored to the nuclear membrane by...
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