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Article

Gene Association Analysis of Quantitative Trait Based on Functional Linear Regression Model with Local Sparse Estimator.

Genes - 30 Mar 2023

Wang Jingyu, Zhou Fujie, Li Cheng, Yin Ning, Liu Huiming, Zhuang Binxian, Huang Qingyu, Wen Yongxian

Abstract excerpt

Functional linear regression models have been widely used in the gene association analysis of complex traits. These models retain all the genetic information in the data and take full advantage of spatial information in genetic variation data, which leads to brilliant detection power. However, the significant association signals identified by the high-power methods are not all the real causal SNPs, because it is...

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PMID: 37107592
DOI: 10.3390/genes14040834
PMCID: PMC10137544

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