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Article

Likelihood ratio tests in rare variant detection for continuous phenotypes.

Annals of human genetics - 1 Sept 2014

Zeng Ping, Zhao Yang, Liu Jin, Liu Liya, Zhang Liwei, Wang Ting, Huang Shuiping, Chen Feng

Abstract excerpt

It is believed that rare variants play an important role in human phenotypes; however, the detection of rare variants is extremely challenging due to their very low minor allele frequency. In this paper, the likelihood ratio test (LRT) and restricted likelihood ratio test (ReLRT) are proposed to test the association of rare variants based on the linear mixed effects model, where a group of rare variants are...

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PMID: 25117149
DOI: 10.1111/ahg.12071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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