Adaptively Integrative Association between Multivariate Phenotypes and Transcriptomic Data for Complex Diseases.

Abstract excerpt

Phenotype-gene association studies can uncover disease mechanisms for translational research. Association with multiple phenotypes or clinical variables in complex diseases has the advantage of increasing statistical power and offering a holistic view. Existing multi-variate association methods mostly focus on SNP-based genetic associations. In this paper, we extend and evaluate two adaptive Fisher's methods,...

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