Article
Phenotype-Dependent Coexpression Gene Clusters: Application to Normal and Premature Ageing.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Wang Kun, Das Avinash, Xiong Zheng-Mei, Cao Kan, Hannenhalli Sridhar
Abstract excerpt
Hutchinson Gilford progeria syndrome (HGPS) is a rare genetic disease with symptoms of aging at a very early age. Its molecular basis is not entirely clear, although profound gene expression changes have been reported, and there are some known and other presumed overlaps with normal aging process. Identification of genes with agingor HGPS-associated expression changes is thus an important problem. However,...
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