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Article

Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors.

Cell chemical biology - 18 May 2023

Lettl Clara, Schindele Franziska, Mehdipour Ahmad Reza, Steiner Thomas, Ring Diana, Brack-Werner Ruth, Stecher Bärbel, Eisenreich Wolfgang, Bilitewski Ursula, Hummer Gerhard, Witschel Matthias, Fischer Wolfgang, Haas Rainer

Abstract excerpt

Respiratory complex I is a multicomponent enzyme conserved between eukaryotic cells and many bacteria, which couples oxidation of electron donors and quinone reduction with proton pumping. Here, we report that protein transport via the Cag type IV secretion system, a major virulence factor of the Gram-negative bacterial pathogen Helicobacter pylori, is efficiently impeded by respiratory inhibition. Mitochondrial...

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PMID: 37100053
DOI: 10.1016/j.chembiol.2023.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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