Article

High-level clarithromycin resistance: a metabolic vulnerability exploited by bismuth in <i>Helicobacter pylori</i>

2026-05-01

Abstract excerpt

<h4>Background & Aims</h4> Clarithromycin (CLA) resistance severely compromises the efficacy of triple therapy (TT) against Helicobacter pylori ( H. pylori ). Bismuth-based regimens exhibit greater efficacy against CLA-resistant H. pylori than against strains resistant to other antibiotics, suggesting a resistance-specific vulnerability rather than broad antimicrobial activity. The mechanistic basis for this s...

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Literature Corpus work: d8ce1100-f652-5899-86f5-9d661f888892
DOI: 10.64898/2026.04.29.26351907

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