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Article

Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics.

Biomaterials - 1 Jul 2024

Lim Byoungjun, Kim Kyoung Sub, Ahn Ji Yong, Na Kun

Abstract excerpt

Herein, we describe the 3'-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria (H. pylori) within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3'-sialyllactose, which exhibits a specific binding affinity for H. pylori surface proteins, and a photosensitizer capable of generating oxygen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38547832
DOI: 10.1016/j.biomaterials.2024.122541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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