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Article

The functional and catalytic landscape of urease reveals a conserved target against Helicobacter pylori.

Gut microbes - 31 Dec 2026

Song Qiang, Wu Huimin, Ma Zhengcai, Huang Ting, Zhu Xinhu, Zhang Zhipeng, Wu Guicheng, Manzoor Rakia, Liu Shiyu, Wang Ye, Li Xuegang, Zhang Wenjin, Ye Xiaoli, Ma Hang

Abstract excerpt

Nearly half of the global population is infected with Helicobacter pylori. Antibiotic use has led to substantial antimicrobial resistance and unintended gut microbiota depletion, creating an urgent need for alternative therapeutic strategies. Here, we demonstrate that urease, a key enzyme that enables H. pylori survival by hydrolysing urea to neutralize stomach acid, is a conserved antibacterial target with low...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41933291
DOI: 10.1080/19490976.2026.2653575
PMCID: PMC13051613

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