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Article

Loss of STK11 Suppresses Lipid Metabolism and Attenuates KRAS-Induced Immunogenicity in Patients with Non-Small Cell Lung Cancer.

Cancer research communications - 1 Aug 2024

Principe Daniel R, Pasquinelli Mary M, Nguyen Ryan H, Munshi Hidayatullah G, Hulbert Alicia, Aissa Alexandre F, Weinberg Frank

Abstract excerpt

As many as 30% of the patients with non-small cell lung cancer harbor oncogenic KRAS mutations, which leads to extensive remodeling of the tumor immune microenvironment. Although co-mutations in several genes have prognostic relevance in KRAS-mutated patients, their effect on tumor immunogenicity are poorly understood. In the present study, a total of 189 patients with non-small cell lung cancer underwent a...

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Identifiers

PMID: 39113608
DOI: 10.1158/2767-9764.CRC-24-0153
PMCID: PMC11362717

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