Article
The association between genetically elevated polyunsaturated fatty acids and risk of cancer.
EBioMedicine - 1 May 2023
Haycock Philip C, Borges Maria Carolina, Burrows Kimberley, Lemaitre Rozenn N, Burgess Stephen, Khankari Nikhil K, Tsilidis Konstantinos K, Gaunt Tom R, Hemani Gibran, Zheng Jie, Truong Therese, Birmann Brenda M, OMara Tracy, Spurdle Amanda B, Iles Mark M, Law Matthew H, Slager Susan L, Saberi Hosnijeh Fatemeh, Mariosa Daniela, Cotterchio Michelle, Cerhan James R, Peters Ulrike, Enroth Stefan, Gharahkhani Puya, Le Marchand Loic, Williams Ann C, Block Robert C, Amos Christopher I, Hung Rayjean J, Zheng Wei, Gunter Marc J, Smith George Davey, Relton Caroline, Martin Richard M
Abstract excerpt
BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in European and East Asian ancestry individuals. We defined the primary exposure as PUFA desaturase activity, proxied by rs174546 at the FADS locus. Secondary exposures were...
Read the complete abstract on PubMed