Article
Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.
European journal of cancer (Oxford, England : 1990) - 1 Oct 2017
May-Wilson Sebastian, Sud Amit, Law Philip J, Palin Kimmo, Tuupanen Sari, Gylfe Alexandra, Hänninen Ulrika A, Cajuso Tatiana, Tanskanen Tomas, Kondelin Johanna, Kaasinen Eevi, Sarin Antti-Pekka, Eriksson Johan G, Rissanen Harri, Knekt Paul, Pukkala Eero, Jousilahti Pekka, Salomaa Veikko, Ripatti Samuli, Palotie Aarno, Renkonen-Sinisalo Laura, Lepistö Anna, Böhm Jan, Mecklin Jukka-Pekka, Al-Tassan Nada A, Palles Claire, Farrington Susan M, Timofeeva Maria N, Meyer Brian F, Wakil Salma M, Campbell Harry, Smith Christopher G, Idziaszczyk Shelley, Maughan Timothy S, Fisher David, Kerr Rachel, Kerr David, Passarelli Michael N, Figueiredo Jane C, Buchanan Daniel D, Win Aung K, Hopper John L, Jenkins Mark A, Lindor Noralane M, Newcomb Polly A, Gallinger Steven, Conti David, Schumacher Fred, Casey Graham, Aaltonen Lauri A, Cheadle Jeremy P, Tomlinson Ian P, Dunlop Malcolm G, Houlston Richard S
Abstract excerpt
BACKGROUND: While dietary fat has been established as a risk factor for colorectal cancer (CRC), associations between fatty acids (FAs) and CRC have been inconsistent. Using Mendelian randomisation (MR), we sought to evaluate associations between polyunsaturated (PUFA), monounsaturated (MUFA) and saturated FAs (SFAs) and CRC risk. METHODS: We analysed genotype data on 9254 CRC cases and 18,386 controls of...
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