Article
Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants: A mendelian randomization study.
Clinical nutrition (Edinburgh, Scotland) - 1 May 2021
Larsson Susanna C, Carter Paul, Vithayathil Mathew, Mason Amy M, Michaëlsson Karl, Baron John A, Burgess Stephen
Abstract excerpt
BACKGROUND & AIMS: Arachidonic acid (AA) is metabolized by cyclooxygenases and lipoxygenases to pro-inflammatory eicosanoids, which according to experimental research modulate tumor cell proliferation, differentiation, and apoptosis. We employed the Mendelian randomization design to test the hypothesis that higher plasma phospholipid AA concentrations are associated with increased risk of 10 site-specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.