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Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study.

Nutrition (Burbank, Los Angeles County, Calif.) - 1 Feb 2023

Chen Jie, Ruan Xixian, Sun Yuhao, Li Xue, Yuan Shuai, Larsson Susanna C

Abstract excerpt

OBJECTIVES: The role of plasma phospholipid arachidonic acid (AA) in the development of non-alcoholic fatty liver disease (NALFD), cirrhosis, and liver cancer remains unclear. This study aimed to determine the causality of the associations of plasma phospholipid AA with NALFD, cirrhosis, and liver cancer using Mendelian randomization analysis. METHODS: Nine independent single-nucleotide polymorphisms associated...

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PMID: 36459845
DOI: 10.1016/j.nut.2022.111910

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