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Protocol for indirect and direct co-culture between human cancer cells and endothelial cells

21 Apr 2023

Abstract excerpt

The cross talk between cancer cells and endothelial cells (ECs) within the tumor microenvironment plays a critical role in tumor progression, recurrence, and cancer stemness. Here, we present a protocol containing two in vitro approaches to study such interactions. We first describe an indirect co-culture system to study the regulation of stemness markers in cancer cells by secreted factors from ECs. We then...

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PMID: 37086411
DOI: 10.1016/j.xpro.2023.102177

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