Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells.

Journal of cell science - 15 Mar 2003

Khodarev Nikolai N, Yu Jianqing, Labay Edwardine, Darga Thomas, Brown Charles K, Mauceri Helena J, Yassari Reza, Gupta Nalin, Weichselbaum Ralph R

Abstract excerpt

Tumour angiogenesis is a complex process based upon a sequence of interactions between tumour cells and endothelial cells. To model tumour/endothelial-cell interactions, we co-cultured U87 human glioma cells with human umbilical vein endothelial cells (HUVECs). U87 cells induced an 'activated' phenotype in HUVECs, including an increase in proliferation, migration and net-like formation. Activation was observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors
Share to Autocrine Communication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Plasminogen

Share to Receptor, TIE-2

Share to Receptors, Cytokine

Share to Receptors, Fibroblast Growth Factor

Share to Receptors, Transforming Growth Factor beta

Share to Umbilical Veins

Source

Identifiers

PMID: 12584245
DOI: 10.1242/jcs.00281

Genes

CALCRL
CCR1
CCR3
CCR5
FGF12
FGF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells.PMID 12584245Read ↗

Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cellsSemantic proximity Read ↗

Differential gene expression by endothelial cells in distinct angiogenic statesSemantic proximity Read ↗

Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cellsSemantic proximity Read ↗

Cytokine networks in solid human tumors: regulation of angiogenesisSemantic proximity Read ↗

Bioengineered three‐dimensional co‐culture of cancer cells and endothelial cells: A model system for dual analysis of tumor growth and angiogenesisSemantic proximity Read ↗

Protocol for indirect and direct co-culture between human cancer cells and endothelial cellsSemantic proximity Read ↗

CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells.Semantic proximity Read ↗

Distinct regulation of gene expression in human endothelial cells by TGF-β and its receptorsSemantic proximity Read ↗

Role of vascular endothelial growth factor in the communication between human osteoprogenitors and endothelial cellsSemantic proximity Read ↗

Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors.Semantic proximity Read ↗

Transcription factor 8 activates R-Ras to regulate angiogenesis.Semantic proximity Read ↗

The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.