Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The association between age at breast cancer diagnosis and prevalence of pathogenic variants.

Breast cancer research and treatment - 1 Jun 2023

Daly Mary B, Rosenthal Eric, Cummings Shelly, Bernhisel Ryan, Kidd John, Hughes Elisha, Gutin Alexander, Meek Stephanie, Slavin Thomas P, Kurian Allison W

Abstract excerpt

PURPOSE: Young age at breast cancer (BC) diagnosis and family history of BC are strongly associated with high prevalence of pathogenic variants (PVs) in BRCA1 and BRCA2 genes. There is limited evidence for such associations with moderate/high penetrance BC-risk genes such as ATM, CHEK2, and PALB2. METHODS: We analyzed multi-gene panel testing results (09/2013-12/2019) for women unaffected by any cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to Breast Cancer Treatment Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Genes, BRCA2

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Global Cancer Incidence and Screening

Share to Prevalence

Source

Open in PubMed Open full text

Identifiers

PMID: 37084156
DOI: 10.1007/s10549-023-06946-8
PMCID: PMC10175307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association between age at breast cancer diagnosis and prevalence of pathogenic variants.PMID 37084156Read ↗

Genomic risk prediction for breast cancer in older womenSemantic proximity Read ↗

Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes.Semantic proximity Read ↗

Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer.Semantic proximity Read ↗

Pathogenic variants among females with breast cancer and a non-breast cancer reveal opportunities for cancer interception.Semantic proximity Read ↗

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score.Semantic proximity Read ↗

Germline pathogenic variant spectrum in 25 cancer susceptibility genes in Turkish breast and colorectal cancer patients and elderly controlsSemantic proximity Read ↗

High likelihood of actionable pathogenic variant detection in breast cancer genes in women with very early onset breast cancer.Semantic proximity Read ↗

Hereditary breast cancer beyond BRCA: clinicopathological characteristics and long-term outcomes.Semantic proximity Read ↗

The impact of coding germline variants on contralateral breast cancer risk and survival.Semantic proximity Read ↗

High- and Moderate-Risk Variants Among Breast Cancer Patients and Healthy Donors Enrolled in Multigene Panel Testing in a Population of Central Russia.Semantic proximity Read ↗

Association of Family Cancer History With Pathogenic Variants in Specific Breast Cancer Susceptibility Genes.Semantic proximity Read ↗

Association of Gene Variant Type and Location with Breast Cancer Risk in the General PopulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.