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Hereditary breast cancer beyond BRCA: clinicopathological characteristics and long-term outcomes.

Familial cancer - 12 Jun 2025

Dejaegher Kwinten, Nevelsteen Ines, Han Sileny, Verhoeven Jelle, Wildiers Hans, Punie Kevin

Abstract excerpt

Limited data exist on hereditary breast cancer characteristics and treatment driven by germline mutations beyond BRCA. Our primary aim is to describe the tumour and patient characteristics, treatment patterns and outcomes in patients with non-BRCA hereditary breast cancer with a focus on CHEK2, ATM, PALB2 and TP53 variants. This is a retrospective single centre hospital-based cohort study of adult patients with a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40504267
DOI: 10.1007/s10689-025-00478-4

Genes

TP53
PALB2
ATM
CHEK2

Provenance

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