Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

High- and Moderate-Risk Variants Among Breast Cancer Patients and Healthy Donors Enrolled in Multigene Panel Testing in a Population of Central Russia.

International journal of molecular sciences - 25 Nov 2024

Shumilova Syuykum, Danishevich Anastasia, Nikolaev Sergey, Krasnov George, Ikonnikova Anna, Isaeva Darya, Surzhikov Sergei, Zasedatelev Alexander, Bodunova Natalia, Nasedkina Tatiana

Abstract excerpt

Assessments of breast cancer (BC) risk in carriers of pathogenic variants identified by gene panel testing in different populations are highly in demand worldwide. We performed target sequencing of 78 genes involved in DNA repair in 860 females with BC and 520 age- and family history-matched controls from Central Russia. Among BC patients, 562/860 (65.3%) were aged 50 years or less at the time of diagnosis. In...

Topics

Humans
Breast Neoplasms
Female
Russia
Middle Aged
Genetic Predisposition to Disease
Adult
BRCA1 Protein
BRCA2 Protein
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

Case-Control Studies

Ataxia Telangiectasia Mutated Proteins

Mutation

Fanconi Anemia Complementation Group N Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 39684352
DOI: 10.3390/ijms252312640
PMCID: PMC11641773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High- and Moderate-Risk Variants Among Breast Cancer Patients and Healthy Donors Enrolled in Multigene Panel Testing in a Population of Central Russia.PMID 39684352Read ↗

Germline pathogenic variant spectrum in 25 cancer susceptibility genes in Turkish breast and colorectal cancer patients and elderly controlsSemantic proximity Read ↗

Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations.Semantic proximity Read ↗

Mutational profile of hereditary breast and ovarian cancer - Establishing genetic testing guidelines in a developing country.Semantic proximity Read ↗

Detection of germline variants in Brazilian breast cancer patients using multigene panel testing.Semantic proximity Read ↗

Germline mutations in 40 cancer susceptibility genes among Chinese patients with high hereditary risk breast cancer.Semantic proximity Read ↗

Pathogenic variants among females with breast cancer and a non-breast cancer reveal opportunities for cancer interception.Semantic proximity Read ↗

Prevention, diagnosis and clinical management of hereditary breast cancer beyond BRCA1/2 genes.Semantic proximity Read ↗

A study of over 35,000 women with breast cancer tested with a 25‐gene panel of hereditary cancer genesSemantic proximity Read ↗

Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer familiesSemantic proximity Read ↗

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer.Semantic proximity Read ↗

Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes.Semantic proximity Read ↗

New germline mutations in BRCA1, ATM, MUTYH, and RAD51D genes in Tuvans early-onset breast cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.