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Article

Association of Family Cancer History With Pathogenic Variants in Specific Breast Cancer Susceptibility Genes.

JCO precision oncology - 1 Jan 2021

Kurian Allison W, Abrahamse Paul, Ward Kevin C, Hamilton Ann S, Deapen Dennis, Berek Jonathan S, Hoang Lily, Yussuf Amal, Dolinsky Jill, Brown Krystal, Slavin Thomas, Hofer Timothy P, Katz Steven J

Abstract excerpt

PURPOSE: Family cancer history is an important component of genetic testing guidelines that estimate which patients with breast cancer are most likely to carry a germline pathogenic variant (PV). However, we do not know whether more extensive family history is differentially associated with PVs in specific genes. METHODS: All women diagnosed with breast cancer in 2013-2017 and reported to statewide SEER...

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Source

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Identifiers

PMID: 34977446
DOI: 10.1200/PO.21.00261
PMCID: PMC8710333

Genes

BRCA1
PALB2
ATM
CHEK2
TP53
BARD1
BRCA2
CDH1
NF1
PTEN
RAD51C
RAD51D

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