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Article

Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer.

Breast cancer research and treatment - 1 Aug 2017

Rummel Seth K, Lovejoy Leann, Shriver Craig D, Ellsworth Rachel E

Abstract excerpt

PURPOSE: Although breast cancer in young women accounts for <10% of diagnoses annually, tumors in young patients exhibit more aggressive characteristics and higher mortality rates. Determination of the frequency of germline mutations in cancer predisposition genes is needed to improve the understanding of breast cancer etiology in young women. METHODS: All female patients enrolled in the Clinical Breast Cancer...

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Source

Identifiers

PMID: 28503720
DOI: 10.1007/s10549-017-4291-8

Genes

BRCA2
CHEK2
APC
ATM
BRCA1
CDH1
MUTYH
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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