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Article

Patients with deleterious germline mutations: A heterogeneous population for pancreatic cancer screening?

Journal of surgical oncology - 1 Aug 2023

Roch Alexandra M, Kim Rachel C, Nguyen Trang K, House Michael G, Zyromski Nicholas J, Nakeeb Attila, Schmidt C Max, Ceppa Eugene P

Abstract excerpt

BACKGROUND AND OBJECTIVES: Modest data exist on the benefits of screening and surveillance for pancreatic cancer (PC) in high-risk individuals. Intraductal papillary mucinous neoplasms (IPMN) are known precursors to PC. We hypothesized that patients with high-risk deleterious germline mutations have a higher prevalence of IPMN. METHODS: All patients undergoing prospective screening at a single institution from...

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Carcinoma, Pancreatic Ductal
Early Detection of Cancer
Genetic Predisposition to Disease
Germ-Line Mutation
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37083062
DOI: 10.1002/jso.27289

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