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Article

Discovering Hereditary Risk Through Surveillance: A Prospective Genetic Analysis of Individuals With Familial Pancreatic Cancer.

United European gastroenterology journal - 1 Feb 2026

Paiella Salvatore, Secchettin Erica, Archibugi Livia, De Luca Raffaele, Bonifacio Cristiana, Laghi Luigi, Lionetto Gabriella, Milanetto Anna Caterina, Sereni Giuliana, Coluccio Chiara, Lauri Gaetano, Dal Buono Arianna, Patruno Margherita, Gabriel Giulia, Sassatelli Romano, Binda Cecilia, Bonvissuto Deborah, Uliana Vera, Malleo Giuseppe, Cavestro Giulia Martina, Terrin Maria, Martino Stefania, Pasquali Claudio, De Pastena Matteo, De Cobelli Francesco, Poletti Valeria, Venturini Elisa, Puzzono Marta, Zerbi Alessandro, Arcidiacono Paolo Giorgio, Salvia Roberto, Falconi Massimo, Capurso Gabriele, Carrara Silvia

Abstract excerpt

BACKGROUND: Little is known about the genetic background of individuals with familial pancreatic cancer (PC). Integrating germline testing into surveillance may uncover previously unrecognized hereditary susceptibility and expand prevention strategies beyond BRCA testing alone. This study evaluated the genetic landscape of high-risk individuals due to familiality (HRI-FHs) enrolled in a national surveillance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41691430
DOI: 10.1002/ueg2.70187
PMCID: PMC12906649

Genes

PC
ATM
BRCA1
PALB2
APC
BRIP1
CFTR
CTRC
MUTYH
SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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