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Article

Lipid dysfunction and pathogenesis of multiple system atrophy.

Acta neuropathologica communications - 7 Feb 2014

Bleasel Jonathan M, Wong Joanna H, Halliday Glenda M, Kim Woojin Scott

Abstract excerpt

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by the accumulation of α-synuclein protein in the cytoplasm of oligodendrocytes, the myelin-producing support cells of the central nervous system (CNS). The brain is the most lipid-rich organ in the body and disordered metabolism of various lipid constituents is increasingly recognized as an important factor in the pathogenesis...

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Identifiers

PMID: 24502382
DOI: 10.1186/2051-5960-2-15
PMCID: PMC3922275

Genes

COQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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