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Genetics of myocardial interstitial fibrosis in the human heart and association with disease

20 Apr 2023

Abstract excerpt

Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse prognosis. Here, to investigate the biological pathways that underlie fibrosis in the human heart, we developed a machine learning model to measure native myocardial T1 time, a marker of myocardial fibrosis, in 41,505 UK Biobank participants who underwent cardiac magnetic resonance imaging. Greater T1 time was associated with...

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PMID: 37081215
DOI: 10.1038/s41588-023-01371-5

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