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Environmental and genetic predictors of human cardiovascular ageing

21 Aug 2023

Abstract excerpt

Cardiovascular ageing is a process that begins early in life and leads to a progressive change in structure and decline in function due to accumulated damage across diverse cell types, tissues and organs contributing to multi-morbidity. Damaging biophysical, metabolic and immunological factors exceed endogenous repair mechanisms resulting in a pro-fibrotic state, cellular senescence and end-organ damage, however...

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PMID: 37604819
DOI: 10.1038/s41467-023-40566-6

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