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Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors

26 Sept 2023

Abstract excerpt

Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic radical-trapping antioxidants (RTAs) reported to block ferroptosis and it is widely used as reference compound. Ferroptosis has been linked to multiple diseases and the use of its inhibitors could have therapeutic potential....

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PMID: 37770317
DOI: 10.1016/j.tips.2023.08.012

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