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Exceptional Response of Pancreatic Acinar Cell Carcinoma and Bile Duct Cancer to Platinum-Based Chemotherapy in a Family With a Germline BRCA2 Variant.

Pancreas - 1 Oct 2022

Sunami Tomohiko, Yamada Atsushi, Kondo Tomohiro, Kanai Masashi, Nagai Kazuyuki, Uchida Yoichiro, Yokode Masataka, Matsumori Tomoaki, Uza Norimitsu, Murakami Hiromi, Yamada Takahiro, Muto Manabu

Abstract excerpt

ABSTRACT: Pancreatic cancer and its rare subtype, acinar cell carcinoma (PACC), frequently harbor germline and/or somatic variants in homologous recombinant genes, including BRCA2. Individuals possessing germline pathogenic BRCA2 variants are known to have a higher risk of developing various cancers, including breast, ovarian, pancreatic, and bile duct cancers (BDCs). It has been reported that tumors positive for...

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Identifiers

PMID: 37078954
DOI: 10.1097/MPA.0000000000002150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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