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Article

Targeting BRCA-mutant biliary tract cancer: Current evidence and future perspectives.

Journal of digestive diseases - 1 Feb 2023

Li Xin Yu, Chen Jia Qi, Aisa Adilai, Ding Yu Wei, Zhang Ding, Yuan Ying

Abstract excerpt

Biliary tract cancers (BTCs) are aggressive tumors of the biliary system, which are often diagnosed at the advanced stage with a dismal prognosis. Among BTC patients, germline or somatic breast cancer-related gene 1/2 (BRCA1/2) mutation has been reported and the use of poly(ADP-ribose) polymerase inhibitor (PARPi) has achieved a certain effect, with no obvious severe side effects. The frequencies and mutated...

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Identifiers

PMID: 36987380
DOI: 10.1111/1751-2980.13168

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