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Genetic Analysis of the ATG16L1 c.898A>G (p.T300A) Variant in Acute and Chronic Pancreatitis.

Pancreas - 1 Oct 2022

Neubauer Claudia, Ewers Maren, Schulz Hans-Ulrich, Weiß Frank Ulrich, Lämmerhirt Felix, Lerch Markus M, Bugert Peter, Landt Olfert, Algül Hana, Rosendahl Jonas, Witt Heiko

Abstract excerpt

OBJECTIVES: Human and animal studies suggest an important role of autophagy in the pathogenesis of pancreatitis. ATG16L1 (autophagy-related 16 like 1) is part of a protein complex that is involved in the formation of autophagosomes. The c.898A > G (p.T300A) variant of ATG16L1 is associated with Crohn disease. In this study, we analyzed ATG16L1 c.898A > G (p.T300A) for an association with pancreatitis. METHODS: We...

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PMID: 37078950
DOI: 10.1097/MPA.0000000000002177

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