Analysis of GPRC6A variants in different pancreatitis etiologies.

doi:10.1016/j.pan.2020.08.001

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Article

Analysis of GPRC6A variants in different pancreatitis etiologies.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Oct 2020

Kaune Tom, Ruffert Claudia, Hesselbarth Nico, Damm Marko, Krug Sebastian, Cardinal von Widdern Julian, Masson Emmanuelle, Chen Jian-Min, Rebours Vinciane, Buscail Louis, Férec Claude, Grützmann Robert, Te Morsche Rene H M, Drenth Joost Ph, Cavestro Giulia Martina, Zuppardo Raffaella Alessia, Saftoiu Adrian, Malecka-Panas Ewa, Głuszek Stanislaw, Bugert Peter, Lerch Markus M, Sendler Matthias, Weiss Frank Ulrich, Zou Wen-Bin, Deng Shun-Jiang, Liao Zhuan, Scholz Markus, Kirsten Holger, Hegyi Peter, Witt Heiko, Michl Patrick, Griesmann Heidi, Rosendahl Jonas

Abstract excerpt

BACKGROUND: The G-protein-coupled receptor Class C Group 6 Member A (GPRC6A) is activated by multiple ligands and is important for the regulation of calcium homeostasis. Extracellular calcium is capable to increase NLRP3 inflammasome activity of the innate immune system and deletion of this proinflammatory pathway mitigated pancreatitis severity in vivo. As such this pathway and the GPRC6A receptor is a...

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PMID: 32859544
DOI: 10.1016/j.pan.2020.08.001

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