Article
Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.
PloS one - 1 Jan 2012
Weis Sebastian, Jesinghaus Moritz, Kovacs Peter, Schleinitz Dorit, Schober Robert, Ruffert Claudia, Herms Max, Wittenburg Henning, Stumvoll Michael, Blüher Matthias, Grützmann Robert, Schulz Hans-Ulrich, Keim Volker, Mössner Joachim, Bugert Peter, Witt Heiko, Drenth Joost P H, Krohn Knut, Rosendahl Jonas
Abstract excerpt
BACKGROUND: Heme oxygenase 1 (HMOX1) is the rate limiting enzyme in heme degradation and a key regulator of inflammatory processes. In animal models the course of pancreatitis was ameliorated by up-regulation of HMOX1 expression. Additionally, carbon monoxide released during heme breakdown inhibited proliferation of pancreatic stellate cells and might thereby prevent the development of chronic pancreatitis (CP)....
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