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Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy

18 Apr 2023

Abstract excerpt

Abstract Background Monocytes -key regulators of the innate immune response- are actively involved in the pathogenesis of systemic lupus erythematosus (SLE). We sought to identify novel compounds that might serve as monocyte-directed targeted therapies in SLE. Results We performed mRNA sequencing in monocytes from 15 patients with active SLE and 10 healthy individuals. Disease activity was assessed with the...

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Share to Chemokine receptors and signaling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37072752
DOI: 10.1186/s12864-023-09275-8

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