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Article

Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing.

Journal of molecular medicine (Berlin, Germany) - 1 May 2020

Han Hua Alexander, Pang Jeremy Kah Sheng, Soh Boon-Seng

Abstract excerpt

The rapid advancement of genome editing technologies has opened up new possibilities in the field of medicine. Nuclease-based techniques such as the CRISPR/Cas9 system are now used to target genetically linked disorders that were previously hard-to-treat. The CRISPR/Cas9 gene editing approach wields several advantages over its contemporary editing systems, notably in the ease of component design, implementation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32198625
DOI: 10.1007/s00109-020-01893-z
PMCID: PMC7220873

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