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CRISPR/Cas9-mediated correction of human genetic disease.

Science China. Life sciences - 1 May 2017

Men Ke, Duan Xingmei, He Zhiyao, Yang Yang, Yao Shaohua, Wei Yuquan

Abstract excerpt

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) protein 9 system (CRISPR/Cas9) provides a powerful tool for targeted genetic editing. Directed by programmable sequence-specific RNAs, this system introduces cleavage and double-stranded breaks at target sites precisely. Compared to previously developed targeted nucleases, the CRISPR/Cas9 system demonstrates several...

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PMID: 28534256
DOI: 10.1007/s11427-017-9032-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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