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Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization

30 Mar 2023

Abstract excerpt

Objectives Our aim was to investigate the interactive causal effects between gut microbiota and host urate metabolism and explore the underlying mechanism using genetic methods. Methods We extracted summary statistics from the abundance of 211 microbiota taxa from the MiBioGen (N =18,340), 205 microbiota metabolism pathways from the Dutch Microbiome Project (N =7738), gout from the Global Biobank Meta-analysis...

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Share to Gout, Hyperuricemia, Uric Acid
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PMID: 37063923
DOI: 10.3389/fimmu.2023.1148591

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