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Biomarkers for chemotherapy and drug resistance in the mismatch repair pathway

1 Apr 2023

Abstract excerpt

Drugs targeting DNA repair have developed rapidly in cancer therapy, and numerous inhibitors have already been utilized in preclinical and clinical stages. To optimize the selection of patients for treatment, it is essential to discover biomarkers to anticipate chemotherapy response. The DNA mismatch repair (MMR) pathway is closely correlated with cancer susceptibility and plays an important role in the...

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PMID: 37060988
DOI: 10.1016/j.cca.2023.117338

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