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Article

SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells

14 Apr 2023

Abstract excerpt

The presence of human cytomegalovirus (HCMV) in glioblastoma (GBM) and improved outcomes of GBM patients receiving therapies targeting the virus have implicated HCMV in GBM progression. However, a unifying mechanism that accounts for the contribution of HCMV to the malignant phenotype of GBM remains incompletely defined. Here we have identified SOX2, a marker of glioma stem cells (GSCs), as a key determinant of...

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PMID: 37058447
DOI: 10.1371/journal.ppat.1011316

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