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Article

EZH2-Myc driven glioblastoma elicited by cytomegalovirus infection of human astrocytes

5 May 2023

Abstract excerpt

Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic virus. HCMV has been detected in malignant gliomas. EZH2 and Myc play a potential oncogenic role, correlating with the glioma grade. Herewith, we present the first experimental evidence for HCMV as a reprogramming vector, straight through the dedifferentiation of mature human astrocytes, and generation of CMV-Elicited...

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PMID: 37147437
DOI: 10.1038/s41388-023-02709-3

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