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Adaptive Evolution of the Spike Protein in Coronaviruses

1 Apr 2023

Abstract excerpt

Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S proteins of coronaviruses and receptors of host cells are extraordinarily complex, with coronaviruses from different genera being able to recognize the same receptor...

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PMID: 37052956
DOI: 10.1093/molbev/msad089

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