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Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups

4 Oct 2006

Abstract excerpt

BACKGROUND: It is believed that animal-to-human transmission of severe acute respiratory syndrome (SARS) coronavirus (CoV) is the cause of the SARS outbreak worldwide. The spike (S) protein is one of the best characterized proteins of SARS-CoV, which plays a key role in SARS-CoV overcoming species barrier and accomplishing interspecies transmission from animals to humans, suggesting that it may be the major...

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PMID: 17020602
DOI: 10.1186/1471-2180-6-88

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