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Article

Rapid and parallel adaptive mutations in spike S1 drive clade success in SARS-CoV-2.

Cell host & microbe - 13 Apr 2022

Kistler Kathryn E, Huddleston John, Bedford Trevor

Abstract excerpt

The SARS-CoV-2 pandemic has resulted in numerous virus variants, some of which have altered receptor-binding or antigenic phenotypes. Here, we quantify the degree to which adaptive evolution is driving the accumulation of mutations across the genome. We correlate clade growth with mutation accumulation, compare rates of nonsynonymous to synonymous divergence, assess temporal clustering of mutations, and evaluate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35364015
DOI: 10.1016/j.chom.2022.03.018
PMCID: PMC8938189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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