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Article

Rare SNPs in receptor tyrosine kinases are negative outcome predictors in multiple myeloma.

Oncotarget - 21 Jun 2016

Keppler Sarah, Weiβbach Susann, Langer Christian, Knop Stefan, Pischimarov Jordan, Kull Miriam, Stühmer Thorsten, Steinbrunn Torsten, Bargou Ralf, Einsele Hermann, Rosenwald Andreas, Leich Ellen

Abstract excerpt

Multiple myeloma (MM) is a plasma cell disorder that is characterized by a great genetic heterogeneity. Recent next generation sequencing studies revealed an accumulation of tumor-associated mutations in receptor tyrosine kinases (RTKs) which may also contribute to the activation of survival pathways in MM. To investigate the clinical role of RTK-mutations in MM, we deep-sequenced the coding DNA-sequence of EGFR,...

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Share to Disease-Free Survival
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27246973
DOI: 10.18632/oncotarget.9607
PMCID: PMC5122427

Genes

EGFR
EPHA2
ERBB3
NTRK1
NTRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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