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Article

Polymorphisms within genes encoding Ikaros family proteins IKZF1 and IKZF3 in multiple myeloma patients treated with thalidomide.

Dental and medical problems - 1 Jan 2000

Łacina Piotr, Porzuczek Diana, Bogunia-Kubik Katarzyna, Mazur Grzegorz, Butrym Aleksandra

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is a hematological malignancy characterized by the presence of abnormal plasma cells. It is associated with anemia, bone lesions and renal dysfunction. Immunomodulatory drugs (IMiDs) are commonly used in MM treatment. Recent studies indicate that their therapeutic effect is caused by binding to cereblon (CRBN), which in turn causes the degradation of 2 important immune cell...

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PMID: 39704419
DOI: 10.17219/dmp/183776

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