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ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels

24 Mar 2023

Abstract excerpt

ADAM10 is the main α-secretase acting in the non-amyloidogenic processing of APP. We hypothesized that certain rare ADAM10 variants could increase the risk for AD by conferring the age-related downregulation of α-secretase. The ADAM10 gene was sequenced in 103 AD cases (82% familial) and 96 cognitively preserved nonagenarians. We examined rare variants (MAF < 0.01) and determined their potential association in...

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PMID: 37047093
DOI: 10.3390/ijms24076113

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