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A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike

4 Aug 2022

Abstract excerpt

Delineating the origins and properties of antibodies elicited by SARS-CoV-2 infection and vaccination is critical for understanding their benefits and potential shortcomings. Therefore, we investigate the SARS-CoV-2 spike (S)-reactive B cell repertoire in unexposed individuals by flow cytometry and single-cell sequencing. We show that ∼82% of SARS-CoV-2 S-reactive B cells harbor a naive phenotype, which...

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PMID: 35927266
DOI: 10.1038/s41467-022-32232-0

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